Rabbit Anti-CHIA/FITC Conjugated antibody

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Acidic mammalian chitinase [Precursor]; AMCase; CHIT2; chitinase, acidic; DKFZp313J1722; ECF L; RP5 1125M8.1; TSA1902.

Cat:

SL13900R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Zebrafish,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CHIA

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

50kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Function:
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.

Subcellular Location:
Isoform 1: Secreted Isoforms 2 and 3: Cytoplasmic

Database links:

Entrez Gene: 27159 Human

Entrez Gene: 81600 Mouse

Entrez Gene: 113901 Rat

GenBank: NM_021797.2 Human

Omim: 606080 Human

SwissProt: Q9BZP6 Human

SwissProt: Q91XA9 Mouse

SwissProt: Q6RY07 Rat

Unigene: 46418 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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