Rabbit Anti-CHMP7/FITC Conjugated antibody

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Charged multivesicular body protein 7; CHMP family member 7; Chromatin modifying protein 7; CHMP7_HUMAN.

Cat:

SL13916R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human CHMP7

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

51kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The charged multivesicular body proteins or chromatin modifying proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP7 is an ESCRT-III-related protein that associates with CHMP4B. CHMP7 contains an SNF7 domain in the SLCterminus and is most similar to CHMP6. CHMP7 also binds to the microtubule interacting and transport (MIT) domain of the deubiquitinating enzyme, UBPY. The overexpression of CHMP7 inhibits EGFR degradation.

Function:
CHMP7 plays a role in the endosomal sorting pathway and is a component of the ESCRT III complex.

Subunit:
Interacts with CHMP4B, but not with VPS25.

Subcellular Location:
Cytoplasm. Note: Diffused localization, with some punctate distribution, especially in the perinuclear area

Similarity:
Belongs to the SNF7 family.

Database links:

Entrez Gene: 91782 Human

Omim: 611130 Human

SwissProt: Q8WUX9 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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