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Home > Product > Antibody > Rabbit Anti-CCK39/FITC Conjugated antibody
CCK; CCK39; Cholecystokinin 39; Cholecystokinin; CCKN_HUMAN.
Cat:
SL13919R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human CCK39
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
11kDa
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Product PDFs
Datasheet:


background:
Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

Function:
Cholecystokinin (CCK) is one of the most important hormone regulators of the digestive process. The peptide is concentrated in the proximal small intestine (CCK cells) and is secreted into the blood in response to the ingestion of proteins and fats, where its actions include the stimulation of pancreatic secretion, the modulation of insulin output, the regulation of gastric emptying, and gallbladder contraction. In the central nervous system CCKergic fibres are widespread, being particularly abundant in the cerebral cortex. In some mesolimbic neurons projecting to the nucleus accumbens, CCK is colocalised with dopamine and it has been suggested that CCK might facilitate the function of dopamine in events such as stimulusreward associative behaviour. Secretion of CCK from the murine tumour cell line STC1 has been shown to be stimulated by pituitary adenylate cyclase activating protein (PACAP) and has raised the possibility that PACAP may function as a neuromodulator of CCK release from gut endocrine cells in vivo.

Subunit:
Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain (By similarity).

Subcellular Location:
Secreted

Post-translational modifications:
The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Similarity:
Belongs to the gastrin/cholecystokinin family.

Database links:

Entrez Gene: 885 Human

Entrez Gene: 12424 Mouse

Entrez Gene: 397468 Pig

Entrez Gene: 25298 Rat

Omim: 11888 Human

SwissProt: P06307 Human

SwissProt: P0948 Mouse

SwissProt: Q53WS9 Mouse

SwissProt: Q8R041 Mouse

SwissProt: Q9DCL5 Mouse

SwissProt: P01356 Pig

SwissProt: P01355 Rat

Unigene: 458426 Human

Unigene: 9781 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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