Function:
Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).
Subunit:
Interacts with PPARA. Probably interacts with ESR1 and NR1I3.
Subcellular Location:
Cytoplasmic and Nuclear
Tissue Specificity:
Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts.
Post-translational modifications:
Phosphorylated on serine and tyrosine residues.
Similarity:
Belongs to the SNF2/RAD54 helicase family.
Contains 2 chromo domains.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
Database links:
Entrez Gene: 80205 Human
Entrez Gene: 109151 Mouse
SwissProt: Q3L8U1 Human
SwissProt: Q8BYH8 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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