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Rabbit Anti-CHST10/FITC Conjugated antibody
background:
This protein encoded by this gene transfers sulfate to the SLC3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
Function:
Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at higher level in the frontal lobe.
Similarity:
Belongs to the sulfotransferase 2 family.
Database links:
Entrez Gene: 9486 Human
Entrez Gene: 98388 Mouse
Entrez Gene: 140568 Rat
Omim: 606376 Human
SwissProt: O43529 Human
SwissProt: Q6PGK7 Mouse
SwissProt: O54702 Rat
Unigene: 516370 Human
Unigene: 731724 Human
Unigene: 260054 Mouse
Unigene: 11224 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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