background:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]
Function:
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the SLC3 hydroxyl. No activity toward dermatan.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney.
Similarity:
Belongs to the sulfotransferase 2 family.
Database links:
Entrez Gene: 166012 Human
Omim: 610124 Human
SwissProt: Q8NET6 Human
Unigene: 292375 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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