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Rabbit Anti-CHST8/FITC Conjugated antibody
background:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Function:
CHST8, or Carbohydrate sulfotransferase 8, catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. CHST8 is only active against terminal GalNAcbeta1 and GalNAcbeta and not toward chondroitin.
Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein.
Similarity:
Belongs to the sulfotransferase 2 family.
Database links:
Entrez Gene: 64377 Human
Entrez Gene: 68947 Mouse
Omim: 610190 Human
SwissProt: Q9H2A9 Human
SwissProt: Q8BQ86 Mouse
SwissProt: B1WBV7 Rat
Unigene: 165724 Human
Unigene: 29380 Mouse
Unigene: 55646 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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