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Rabbit Anti-SIGIRR/FITC Conjugated antibody
background:
Single Ig IL-1-related receptor SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut.
Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Subcellular Location:
Membrane.
Tissue Specificity:
Mainly expressed in epithelial tissues such as kidney, lung and gut.
Similarity:
Belongs to the interleukin-1 receptor family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 TIR domain.
Database links:
Entrez Gene: 59307 Human
Entrez Gene: 4858 Mouse
Entrez Gene: 309106 Rat
Omim: 605478 Human
SwissProt: Q6IA17 Human
SwissProt: Q9JLZ8 Mouse
SwissProt: Q4V892 Rat
Unigene: 501624 Human
Unigene: 38017 Mouse
Unigene: 16525 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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