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Rabbit Anti-Cyclooxygenase 2/FITC Conjugated antibody
background:
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
Function:
Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Subunit:
Homodimer.
Subcellular Location:
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Post-translational modifications:
S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561.
Similarity:
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.
Database links:
Entrez Gene: 5743 Human
Entrez Gene: 19225 Mouse
Entrez Gene: 29527 Rat
Omim: 600262 Human
SwissProt: P35354 Human
SwissProt: Q05769 Mouse
SwissProt: P35355 Rat
Unigene: 196384 Human
Unigene: 292547 Mouse
Unigene: 44369 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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