Rabbit Anti-CIP29/FITC Conjugated antibody

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Cytokine induced protein of 29 kDa; Cytokine-induced protein of 29 kDa; HCC 1; HCC1; HSPC316; Nuclear protein Hcc 1; Nuclear protein Hcc-1; Proliferation associated cytokine inducible protein CIP29; Proliferation-associated cytokine-inducible prot

Cat:

SL13957R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CIP29

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

24kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CIP29 is a 210 amino acid nuclear protein whose expression is upregulated by erythropoietin. Induction of CIP2 expression is associated with cell cycle progression and apoptosis. This transcription factor binds both single stranded (ss) and double stranded (ds) DNA, though it has higher affinity for ssDNA. CIP29 is expressed at low levels in pancreas, spleen, testis, liver, kidney, heart and thymus, and is found to be expressed at higher levels in pancreatic adenocarcinoma and hepatocellular carcinoma. A translocation t(11;12)(q23;q13) in acute myelomonocytic leukemia results in the coding region of CIP29 gene fused to exon 9 of the MLL gene, which encodes for a protein with the N-terminal SAP domain and two SLCterminal nuclear localization signals of CIP29 and N-termial AT hooks and central DNA methyltransferase homology region of MLL.

Function:
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis.

Subcellular Location:
Nucleus.

Tissue Specificity:
Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.

Similarity:
Contains 1 SAP domain.

Database links:

Entrez Gene: 84324 Human

Entrez Gene: 732539 Cow

Entrez Gene: 66118 Mouse

Entrez Gene: 362819 Rat

Omim: 610049 Human

SwissProt: P82979 Human

SwissProt: Q9D1J3 Mouse

SwissProt: Q498U4 Rat

Unigene: 505676 Human

Unigene: 351579 Mouse

Unigene: 1506 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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