Home
>
Product
>
Antibody
>
Rabbit Anti-Calbindin/FITC Conjugated antibody
background:
Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted. [provided by RefSeq, Jul 2008]
Function:
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Subunit:
Interacts with RANBP9.
Similarity:
Belongs to the calbindin family.
Contains 5 EF-hand domains.
Database links:
Entrez Gene: 793 Human
Entrez Gene: 12307 Mouse
Entrez Gene: 83839 Rat
Omim: 114050 Human
SwissProt: P05937 Human
SwissProt: P12658 Mouse
SwissProt: P07171 Rat
Unigene: 65425 Human
Unigene: 277665 Mouse
Unigene: 3908 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|