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Home > Product > Antibody > Rabbit Anti-Constitutive androstane receptor/FITC Conjugated antibody
CAR; CAR BETA; CAR1; CARA; Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; MGC97144; NR1I3; NR1I3_HUMAN; Nuclear receptor subfamily 1 group I member 3; Orphan nuclear receptor MB67;
Cat:
SL13972R-FITC
Species Reactivity：
(predicted: Human,Chimpanzee,)
Immunogen：
KLH conjugated synthetic peptide derived from human Constitutive androstane receptor
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
45kDa
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Product PDFs
Datasheet:


background:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm; cytoskeleton. Recruited to the cytoplasm by DNAJC7.

Tissue Specificity:
Predominantly expressed in liver.

Post-translational modifications:
Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 9970 Human

Entrez Gene: 12355 Mouse

Entrez Gene: 65035 Rat

Omim: 603881 Human

SwissProt: Q14994 Human

SwissProt: O35627 Mouse

SwissProt: Q9QUS1 Rat

Unigene: 349642 Human

Unigene: 486506 Mouse

Unigene: 163229 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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