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Rabbit Anti-phospho-Cortactin (Tyr421)/FITC Conjugated antibody
background:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Function:
Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.
Post-translational modifications:
Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
Similarity:
Contains 7 cortactin repeats.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 2017 Human
Entrez Gene: 13043 Mouse
Entrez Gene: 60465 Rat
GenBank: NM_138565 Human
GenBank: NM_007803 Mouse
Omim: 164765 Human
SwissProt: Q14247 Human
SwissProt: Q60598 Mouse
Unigene: 596164 Human
Unigene: 205601 Mouse
Unigene: 107869 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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