Rabbit Anti-ERPINA6/Cortisol Binding Globulin/FITC Conjugated antibody

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CBG; CBG_HUMAN; corticosteroid binding globulin; Corticosteroid-binding globulin; serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6; serpin A6; serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitr

Cat:

SL14001R-FITC

Species Reactivity：

(predicted: Human,Mouse,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Cortisol Binding Globulin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

43kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Subcellular Location:
Secreted.

Tissue Specificity:
Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

Post-translational modifications:
N-glycosylated; binds 5 oligosaccharide chains.
Glycosylation in position Asn-260 is needed for steroid binding.

DISEASE:
Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.

Similarity:
Belongs to the serpin family.

Database links:

Entrez Gene: 866 Human

Omim: 122500 Human

SwissProt: P08185 Human

Unigene: 532635 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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