background:
The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. Localized to the intermembrane space, COX6b2 (Cytochrome c oxidase subunit 6B2), also known as Cytochrome c oxidase subunit VIb isoform 2 and Cancer/testis antigen 59, is a 88 amino acid mitochondrial protein that is responsible for joining the two COX monomers to form the COX dimer. COX6b2 is specifically expressed in testis and is found to be upregulated in certain cancer cell lines.
Function:
Connects the two COX monomers into the physiological dimeric form.
Subcellular Location:
Mitochondrion intermembrane space.
Tissue Specificity:
Testis specific. Weak expression in thymus and heart. Expressed in cancer cell lines.
Similarity:
Belongs to the cytochrome c oxidase subunit 6B family.
Database links:
Entrez Gene: 125965 Human
Entrez Gene: 333182 Mouse
Entrez Gene: 654441 Rat
SwissProt: Q6YFQ2 Human
SwissProt: Q80ZN9 Mouse
SwissProt: Q6YFQ1 Rat
Unigene: 550544 Human
Unigene: 29625 Mouse
Unigene: 97699 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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