background:
The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water and ATP. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. The COX8 (cytochrome c oxidase subunit VIII) subunits are nuclear and have muscle and non-muscle-specific isoforms. COX8 exists as three isoforms: COX8a, a liver and heart isoform, Cox8b, a heart-specific isoform, and Cox8c, whose expression pattern has yet to be elucidated. All three Cox8 isoforms exists as components of the COX complex and play an important role in electron transport.
Function:
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular Location:
Mitochondrion inner membrane.
Tissue Specificity:
It is not yet known where COX8C is expressed.
Similarity:
Belongs to the cytochrome c oxidase VIII family.
Database links:
Entrez Gene: 341947 Human
Entrez Gene: 75483 Mouse
Entrez Gene: 72229 Rat
SwissProt: Q7Z4L0 Human
SwissProt: A6H666 Mouse
SwissProt: Q7TNN2 Rat
Unigene: 666459 Human
Unigene: 660 Mouse
Unigene: 98192 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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