Rabbit Anti-CPN1/FITC Conjugated antibody

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ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N catalytic chain; Carboxypeptidase N polypeptide 1; Carboxypeptidase N polypeptide 1 50 kD; Carboxypeptidase N small subunit; CBPN_HUMAN; CPN; CPN1; Kininase 1; Kininase-1; Kini

Cat:

SL14023R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CPN1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

52kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

Function:
Protects the body from potent vasoactive and inflammatory peptides containing SLCterminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.

Subcellular Location:
Secreted > extracellular space.

Tissue Specificity:
Synthesized in the liver and secreted in plasma.

DISEASE:
Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.

Similarity:
Belongs to the peptidase M14 family.

Database links:

Entrez Gene: 1369 Human

Entrez Gene: 93721 Mouse

Entrez Gene: 365466 Rat

Omim: 603103 Human

SwissProt: Q2KJ83 Cow

SwissProt: P15169 Human

SwissProt: Q9JJN5 Mouse

SwissProt: Q9EQV8 Rat

Unigene: 2246 Human

Unigene: 206774 Mouse

Unigene: 145303 Rat

Unigene: 162532 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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