background:
Copine I is a member of the copine family of evolutionarily conserved, soluble, calcium-dependent, membrane-binding proteins. Members of the copine family are involved in signal transduction and membrane trafficking. Copine I is ubiquitously expressed and contains two N-terminal C2 domains and one SLCterminal VWFA (von Willebrand factor A) domain, which is also referred to as the A domain or the core domain. As is characteristic of the copine family, copine I functions in membrane trafficking and is capable of binding phospholipids in a calcium-dependent manner. Copine I is also able to bind liposomes. Via its VWFA domain, copine I directly interacts with the ubiquitin-conjugating enzyme, UBC12, and may play a role in the regulation of TNF alpha-signaling.
Function:
May function in membrane trafficking. Exhibits calcium-dependent phospholipid binding properties.
Subunit:
Interacts with CCDC22.
Similarity:
Belongs to the copine family.
Contains 2 C2 domains.
Contains 1 VWFA domain.
Database links:
Entrez Gene: 615677 Cow
Entrez Gene: 477213 Dog
Entrez Gene: 8904 Human
Entrez Gene: 266692 Mouse
Entrez Gene: 100233174 Pig
Entrez Gene: 100328904 Rabbit
Omim: 604205 Human
SwissProt: Q99829 Human
SwissProt: Q8C166 Mouse
Unigene: 246413 Human
Unigene: 700188 Human
Unigene: 27660 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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