Rabbit Anti-CPSF1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-CPSF1/FITC Conjugated antibody

Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; CPSF160; HSU37012; P/cl.18.

Cat:

SL14035R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human CPSF1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

161kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

Function:
CPSF1 (Cleavage and polyadenylation specificity factor subunit 1) is a component of the cleavage and polyadenylation specificity factor (CPSF) complex. It plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Subcellular Location:
Nucleus, nucleoplasm.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the CPSF1 family.

Database links:

Entrez Gene: 29894 Human

Entrez Gene: 94230 Mouse

Entrez Gene: 366952 Rat

Omim: 606027 Human

SwissProt: Q10570 Human

SwissProt: Q9EPU4 Mouse

SwissProt: B5DEL2 Rat

Unigene: 49642 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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