background:
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
Function:
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.
Subcellular Location:
Nucleus. In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the RRM CPSF6/7 family.
Contains 1 RRM (RNA recognition motif) domain.
Database links:
Entrez Gene: 11052 Human
Entrez Gene: 417844 Chicken
Entrez Gene: 768231 Cow
Entrez Gene: 432508 Mouse
Entrez Gene: 299811 Rat
Entrez Gene: 446580 Xenopus laevis
Omim: 604979 Human
SwissProt: Q5ZL34 Chicken
SwissProt: Q0P5D2 Cow
SwissProt: Q16630 Human
SwissProt: Q6NVF9 Mouse
SwissProt: Q6DDW4 Xenopus laevis
Unigene: 369606 Human
Unigene: 478881 Mouse
Unigene: 478884 Mouse
Unigene: 479892 Mouse
Unigene: 7296 Xenopus laevis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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