background:
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]
Function:
Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Database links:
Entrez Gene: 1381 Human
Entrez Gene: 374211 Chicken
Entrez Gene: 282201 Cow
Entrez Gene: 12903 Mouse
Entrez Gene: 25061 Rat
Omim: 36230 Human
SwissProt: P40220 Chicken
SwissProt: P62964 Cow
SwissProt: P29762 Human
SwissProt: P62965 Mouse
SwissProt: P62966 Rat
Unigene: 346950 Human
Unigene: 34797 Mouse
Unigene: 647 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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