Rabbit Anti-CREB3L1/FITC Conjugated antibody

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BBF-2 homolog; CAMP responsive element binding protein 3 like 1; cAMP-responsive element-binding protein 3-like protein 1; CR3L1_HUMAN; Creb3l1; Cyclic AMP responsive element binding protein 3 like protein 1; OASIS; Old astrocyte specifically-induced subs

Cat:

SL14051R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CREB3L1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

57kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

Function:
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.

Subcellular Location:
Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Tissue Specificity:
Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.

Post-translational modifications:
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.

Similarity:
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.

Database links:

Entrez Gene: 90993 Human

Entrez Gene: 26427 Mouse

Entrez Gene: 362165 Rat

SwissProt: Q96BA8 Human

SwissProt: Q9Z125 Mouse

SwissProt: Q66HA2 Rat

Unigene: 405961 Human

Unigene: 10353 Mouse

Unigene: 24541 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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