background:
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Function:
Binds to the cAMP response element and activates transcription.
Subunit:
Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the bZIP family.
Contains 1 bZIP domain.
Contains 1 C2H2-type zinc finger.
Database links:
Entrez Gene: 9586 Human
Entrez Gene: 231991 Mouse
Entrez Gene: 500131 Rat
SwissProt: Q02930 Human
SwissProt: Q8K1L0 Mouse
Unigene: 437075 Human
Unigene: 32228 Mouse
Unigene: 210235 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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