Rabbit Anti-CRISP2/FITC Conjugated antibody

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Cancer/testis antigen 36; CRIS2_HUMAN; CRISP 2; CRISP-2; CRISP2; CT36; Cysteine rich secretory protein 2; Cysteine-rich secretory protein 2; GAPDL5; Glyceraldehyde 3 phosphate dehydrogenase like 5; Testis specific protein 1 (probe H4 1 p3 1); Testis speci

Cat:

SL14059R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human CRISP2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

21kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins which may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. CRISP-1 coats the postacrosomal region of sperm heads as they pass through the epididymis. CRISP-1 is found in all regions of the epididymis, ductus deferens, seminal plasma and sperm. CRISP-2, also known as testis-specific protein TPX1 or cancer/testis antigen 36 (CT36), is a 243 amino acid secreted protein. Expressed in the testis and epididymis, CRISP-2 is thought to be involved in calcium fluxes during sperm capacitation by regulating the activity of certain ion channels. CRISP-3 is expressed in pancreas and prostate tissues and, along with CRISP-1, is expressed in saliva. The gene that encodes CRISP-3 is an early response gene that may participate in the pathophysiology of the auto-immune lesions of Sjogren’s syndrome.

Function:
May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.

Subcellular Location:
Secreted.

Tissue Specificity:
Testis and epididymis.

Similarity:
Belongs to the CRISP family.

Database links:

Entrez Gene: 736 Human

Omim: 187430 Human

SwissProt: P16562 Human

Unigene: 2042 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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