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Rabbit Anti-GLUT2/FITC Conjugated antibody
background:
Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq, Jul 2008].
Function:
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Liver, insulin-producing beta cell, small intestine and kidney.
Post-translational modifications:
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
DISEASE:
Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS) [MIM:227810]. FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
Similarity:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Database links:
Entrez Gene: 6514 Human
Entrez Gene: 20526 Mouse
Entrez Gene: 25351 Rat
Omim: 138160 Human
SwissProt: P11168 Human
SwissProt: P14246 Mouse
SwissProt: P12336 Rat
Unigene: 167584 Human
Unigene: 18443 Mouse
Unigene: 89295 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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