background:
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Function:
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.
Similarity:
Belongs to the CTP synthase family.
Contains 1 glutamine amidotransferase type-1 domain.
Database links:
Entrez Gene: 56474 Human
Entrez Gene: 767849 Cow
Entrez Gene: 55936 Mouse
Entrez Gene: 619580 Rat
Omim: 300380 Human
SwissProt: Q5F3Z1 Chicken
SwissProt: Q1RMS2 Cow
SwissProt: Q9NRF8 Human
SwissProt: P70303 Mouse
SwissProt: Q5U2N0 Rat
Unigene: 227049 Human
Unigene: 2065 Mouse
Unigene: 13683 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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