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Rabbit Anti-CYB5R2/FITC Conjugated antibody
background:
NADH-cytochrome b5 reductases participate in a variety of physiological processes including biosynthesis of cholesterol, methemoglobin reduction of erythrocytes, elongation of fatty acids and metabolism of drugs. CYB5R2 (cytochrome b5 reductase 2), also known as B5R.2, is a 276 amino acid protein that contains one FAD-binding FR-type domain and belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. Existing as two alternatively spliced isoforms, CYB5R2 reduces 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt and lucigenin in spermatozoa, which results in NADH-dependent lucigenin chemiluminescence. CYB5R2 binds FAD as a cofactor and is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
Function:
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1).
Tissue Specificity:
Restricted expression.
Similarity:
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Contains 1 FAD-binding FR-type domain.
Database links:
Entrez Gene: 51700 Human
Entrez Gene: 64635 Mouse
Entrez Gene: 365345 Rat
Omim: 608342 Human
SwissProt: Q6BCY4 Human
SwissProt: Q3KNK3 Mouse
SwissProt: Q6AY12 Rat
Unigene: 414362 Human
Unigene: 132828 Mouse
Unigene: 16198 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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