Rabbit Anti-CYB5R4/FITC Conjugated antibody

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b5+b5R; b5b5r; C79736; cb5/cb5R; Cb5cb5r; Cyb5r4; Cytochrome b type NAD(P)H oxidoreductase; Cytochrome b5 reductase 4; dJ676J13.1; Flavohemoprotein b5+b5R; Flavohemoprotein b5/b5R; N terminal cytochrome b5 and cytochrome b5 oxidoreductase domain containin

Cat:

SL14133R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CYB5R4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

59kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]

Function:
NADH-cytochrome b5 reductase involved in endolasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

Subcellular Location:
Endoplasmic reticulum. Soluble protein.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Contains 1 CS domain.
Contains 1 cytochrome b5 heme-binding domain.
Contains 1 FAD-binding FR-type domain.

Database links:

Entrez Gene: 51167 Human

Omim: 608343 Human

SwissProt: Q7L1T6 Human

Unigene: 5741 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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