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Rabbit Anti-phospho-Cyclin C (Ser275)/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (SLCterminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the cyclin family. Cyclin C subfamily.
Contains 1 cyclin N-terminal domain.
Database links:
Entrez Gene: 892 Human
Entrez Gene: 51813 Mouse
Entrez Gene: 114839 Rat
Omim: 123838 Human
SwissProt: P24863 Human
SwissProt: Q62447 Mouse
SwissProt: P39947 Rat
Unigene: 430646 Human
Unigene: 278584 Mouse
Unigene: 106758 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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