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Rabbit Anti-Cyclophilin E/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010]
Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding and PPIase activities. May be involved in muscle- and brain-specific processes. May be involved in pre-mRNA splicing.
Subcellular Location:
Nucleus.
Tissue Specificity:
Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Similarity:
Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.
Contains 1 PPIase cyclophilin-type domain.
Contains 1 RRM (RNA recognition motif) domain.
Database links:
Entrez Gene: 10450 Human
Entrez Gene: 787681 Cow
Entrez Gene: 56031 Mouse
Entrez Gene: 298508 Rat
Omim: 602435 Human
SwissProt: A4FV72 Cow
SwissProt: Q9UNP9 Human
SwissProt: Q9QZH3 Mouse
Unigene: 524690 Human
Unigene: 126873 Mouse
Unigene: 18887 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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