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Rabbit Anti-CYLC2/FITC Conjugated antibody
background:
Cylicin-2 is a 348 amino acid protein encoded by the human gene CYLC2. Cylicin-1 is a type of a cytoskeletal protein which contains numerous Lys-Lys-Asp tripeptides accumulated in nine central repetitive units predicted to form a-helices. Cylicin-2, present in cow and human sperm heads, has the same prominent molecular characteristics as Cylicin-1, including a high content of charged amino acids, the abundance of Lys-Lys-Asp tripeptides and repetitive units of presumably a-helical configuration. Cylicin-2 is found in the acrosomal region of round spermatids and in the post-acrosomal region of late spermatids and spermatozoa, in agreement with the localization of Cylicin-1. Cylicin-2 is a novel Actin-binding protein, which probably plays a role in the Actin-related events that occur during spermiogenesis and the early events of fertilization.
Function:
CYCL2 (Cylicin II) is specifically expressed in testis and is part of the cytoskeletal calyx of mammalian sperm heads. Cylicin II may play a role in the morphogenesis of the sperm head and may be involved in spermatid differentiation.
Subcellular Location:
Cytoplasm, cytoskeleton, perinuclear theca, calyx. Note=Sperm head cytoskeletal structure.
Tissue Specificity:
Testis.
Database links:
Entrez Gene: 1537 Human
Entrez Gene: 1539 Human
Omim: 604035 Human
SwissProt: P08574 Human
SwissProt: Q14093 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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