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Rabbit Anti-CYP2F1/FITC Conjugated antibody
background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Function:
May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses no activity toward ethoxyresorufin and only trace dearylation activity toward benzyloxyresorufin. Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine.
Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein (Probable). Microsome membrane; Peripheral membrane protein.
Tissue Specificity:
Expressed in lung. Rarely detected in liver and placenta.
Similarity:
Belongs to the cytochrome P450 family.
Database links:
Entrez Gene: 1572 Human
Omim: 14870 Human
SwissProt: P24903 Human
Unigene: 558318 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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