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Rabbit Anti-Claudin 5/FITC Conjugated antibody
background:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space.
Subunit:
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ.
Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Similarity:
Belongs to the claudin family.
Database links:
Entrez Gene: 7122 Human
Entrez Gene: 12741 Mouse
Omim: 602101 Human
SwissProt: Q2HJ22 Cow
SwissProt: O00501 Human
SwissProt: O54942 Mouse
Unigene: 505337 Human
Unigene: 22768 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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