Rabbit Anti-TAP1/FITC Conjugated antibody

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ABC transporter MHC 1; ABC17; ABCB 2; ABCB2; Antigen peptide transporter 1; APT 1; APT1; ATP binding cassette sub family B (MDR/TAP) member 2; ATP binding cassette sub family B member 2; ATP binding cassette transporter; D6S114E; FLJ26666; FLJ41500; Pepti

Cat:

SL10632R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TAP1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

87kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

Function:
Involved in the transport of antigens from the cytoplasmto the endoplasmic reticulum for association with MHC class Imolecules. Also acts as a molecular scaffold for the final stage ofMHC class I folding, namely the binding of peptide. Nascent MHCclass I molecules associate with TAP via tapasin. Inhibited by thecovalent attachment of herpes simplex virus ICP47 protein, whichblocks the peptide-binding site of TAP. Inhibited by humancytomegalovirus US6 glycoprotein, which binds to the lumenal sideof the TAP complex and inhibits peptide translocation byspecifically blocking ATP-binding to TAP1 and prevents theconformational rearrangement of TAP induced by peptide binding.Inhibited by human adenovirus E3-19K glycoprotein, which binds theTAP complex and acts as a tapasin inhibitor, preventing MHC classI/TAP association. Expression of TAP1 is down-regulated by humanEpstein-Barr virus vIL-10 protein, thereby affecting the transportof peptides into the endoplasmic reticulum and subsequent peptideloading by MHC class I molecules.

Subunit:
Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barrvirus BNLF2a. Interacts with PSMB5 and PSMB8.

Subcellular Location:
Endoplasmic reticulum membrane; Multi-passmembrane protein. Note=The transmembrane segments seem to form apore in the membrane.

DISEASE:
Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLAclass I deficiency. Contrary to bare lymphocyte syndromes type 2and type 3, which are characterized by early-onset severe combinedimmunodeficiency, class I antigen deficiencies are not accompaniedby particular pathologic manifestations during the first years oflife. Systemic infections have not been described. Chronicbacterial infections, often beginning in the first decade of life,are restricted to the respiratory tract. Note=The disease is causedby mutations affecting the gene represented in this entry.

Similarity:
Belongs to the ABC transporter superfamily. ABCBfamily. MHC peptide exporter (TC 3.A.1.209) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 1 ABC transporter domain.

Database links:

Entrez Gene: 6890 Human

Entrez Gene: 24811 Rat

Omim: 170260 Human

SwissProt: Q03518 Human

SwissProt: P36370 Rat

Unigene: 352018 Human

Unigene: 10763 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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