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Rabbit Anti-SCP3/FITC Conjugated antibody
background:
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]
Function:
Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
Subunit:
Interacts with SYCP2.
Subcellular Location:
Nucleus. Chromosome. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.
Tissue Specificity:
Testis-specific.
Post-translational modifications:
Phosphorylated.
DISEASE:
Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the XLR/SYCP3 family.
Database links:
Entrez Gene: 50511 Human
Entrez Gene: 20962 Mouse
Entrez Gene: 25561 Rat
Omim: 604759 Human
SwissProt: Q8IZU3 Human
SwissProt: P70281 Mouse
SwissProt: Q63520 Rat
Unigene: 506504 Human
Unigene: 297977 Mouse
Unigene: 34889 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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