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Rabbit Anti-DECR2/FITC Conjugated antibody
background:
DECR2 is a 292 amino acid member of the short-chain dehydrogenases/reductases (SDR) protein family and the 2,4-dienoyl-CoA reductase protein subfamily. Localized to the peroxisome, DECR2 is an auxiliary enzyme of beta-oxidation that catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. DECR2 has also been shown to have catalytic activity towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA and short and medium chain 2,4-dienoyl-CoAs, suggesting that DECR2 is not a rate limiting step in the degradation of docosahexaenoic acid in the peroxisome. DECR2 is expressed as three isoforms produced by alternative splicing events.
Function:
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Subunit:
Monomer, dimer and oligomer.
Subcellular Location:
Peroxisome.
Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
Database links:
Entrez Gene: 26063 Human
Entrez Gene: 26378 Mouse
Entrez Gene: 64461 Rat
SwissProt: Q9NUI1 Human
SwissProt: Q9WV68 Mouse
SwissProt: Q9Z2M4 Rat
Unigene: 628831 Human
Unigene: 655999 Human
Unigene: 292869 Mouse
Unigene: 144598 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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