background:
Beta-defensins are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. The family of Beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many Beta-defensins also are involved in sperm maturation and capacitation. Beta-defensin 124 is a 71 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active.
Function:
DEFB124 has antibacterial activity.
Subcellular Location:
Secreted
Similarity:
Belongs to the beta-defensin family.
Database links:
Entrez Gene: 245934 Human
SwissProt: Q8NES8 Human
Unigene: 381373 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
