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Rabbit Anti-phospho-delta 1 Catenin (Tyr280)/FITC Conjugated antibody
background:
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
Function:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both SLC and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 SLCterminal cleavage.
Subcellular Location:
Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
Tissue Specificity:
Expressed in vascular endothelium.
Post-translational modifications:
Phosphorylated by protein-tyrosine kinases. Dephosphorylated by PTPRJ.
Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.
Database links:
Entrez Gene: 300 Human
Entrez Gene: 12388 Mouse
Entrez Gene: 311163 Rat
Omim: 601045 Human
SwissProt: O60716 Human
SwissProt: P30999 Mouse
Unigene: 166011 Human
Unigene: 35738 Mouse
Unigene: 9435 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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