background:
This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
DGKG (Diacylglycerol kinase gamma ) reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid. This enzyme initiates resynthesis of phosphoinositides consumed by phospholipase C during cellular signal transduction. DGK gamma is one of multiple DGK isozymes found in animal cells. It is expressed abundantly in the human retina and to a much lesser extent in the brain. Other tissues contain extremely low levels.
Subcellular Location:
Cell Membrane and Cytoplasmic.
Database links:
Entrez Gene: 1608 Human
Entrez Gene: 110197 Mouse
Entrez Gene: 25666 Rat
Omim: 601854 Human
SwissProt: P49619 Human
SwissProt: Q2M1H4 Human
SwissProt: Q5FWG1 Human
SwissProt: Q91WG7 Mouse
SwissProt: P49620 Rat
Unigene: 683449 Human
Unigene: 194986 Mouse
Unigene: 10544 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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