Rabbit Anti-DGKD/FITC Conjugated antibody

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130 kDa diacylglycerol kinase; DAG kinase delta; DGK delta; DGK-delta; DGKD; DGKD_HUMAN; DGKdelta; Diacylglycerol kinase delta; Diglyceride kinase delta; FLJ26930; KIAA0145.

Cat:

SL14296R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human DGKD

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

134kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function:
May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis.

Subcellular Location:
Cytoplasm and Membrane.

Tissue Specificity:
Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells.

Post-translational modifications:
Isoform 1 H domain is phosphorylated.

Similarity:
Belongs to the eukaryotic diacylglycerol kinase family.
Contains 1 DAGKc domain.
Contains 1 PH domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Contains 1 SAM (sterile alpha motif) domain.

Database links:

Entrez Gene: 8527 Human

Omim: 601826 Human

SwissProt: Q16760 Human

Unigene: 471675 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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