background:
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
Function:
DGKK (Diacylglycerol kinase kappa) phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
Subunit:
Does not form homooligomers.
Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein
Tissue Specificity:
Expressed in testis, and to a lesser extent in placenta.
Post-translational modifications:
Phosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2).
Similarity:
Belongs to the eukaryotic diacylglycerol kinase family.
Contains 1 DAGKc domain.
Contains 1 PH domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Database links:
Entrez Gene: 139189 Human
Entrez Gene: 331374 Mouse
SwissProt: Q5KSL6 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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