Rabbit Anti-DHX58/FITC Conjugated antibody

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D11LGP2; D11lgp2e; DEXH (Asp Glu X His) box polypeptide 58; DEXH box polypeptide 58; DHX 58; DHX58; DHX58_HUMAN; LGP 2; LGP2; Ortholog of mouse D11lgp2; Probable ATP dependent helicase LGP2; Probable ATP dependent RNA helicase DHX58; Probable ATP-dependen

Cat:

SL14323R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human DHX58

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

77kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase SLCterminal domain.

Function:
Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower.

Subcellular Location:
Cytoplasm.

Similarity:
Belongs to the helicase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.

Database links:

Entrez Gene: 79132 Human

Entrez Gene: 80861 Mouse

Entrez Gene: 303538 Rat

Omim: 608588 Human

SwissProt: Q96C10 Human

SwissProt: Q99J87 Mouse

Unigene: 55918 Human

Unigene: 271830 Mouse

Unigene: 105654 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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