background:
DLK2 is a 383 amino acid single-pass transmembrane protein with six tandem EGF-like repeats in the putative extracellular domain, which is characteristic of the EGF-like protein family. DLK2 shares nearly identical structural features with DLK, suggesting that it may function in a similar way. Like DLK, DLK2 affects adipogenesis of 3T3-L1 preadipocytes and mesenchymal C3H10T1/2 cells, yet it does so in an opposite way to that of DLK. Also, expression of DLK and DLK2 are inversely correlated and changes in expression of one gene will affect the expression levels of the other. Therefore, it is likely that adipogenesis is modulated by the coordinated expression of DLK and DLK2. There are two isoforms of DLK2 that are produced as a result of alternative splicing events.
Function:
Regulates adipogenesis.
Subcellular Location:
Membrane.
Similarity:
Contains 6 EGF-like domains.
Database links:
Entrez Gene: 65989 Human
Entrez Gene: 106565 Mouse
SwissProt: Q6UY11 Human
SwissProt: Q8K1E3 Mouse
Unigene: 337251 Human
Unigene: 23633 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|