Rabbit Anti-DLX3/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-DLX3/FITC Conjugated antibody

AI4; Distal less homeo box 3; DLX 3; Dlx3; DLX3 distalless homeobox 3; DLX3_HUMAN; Homeobox protein DLX 3; Homeobox protein DLX-3; Homeobox protein Dlx3; TDO.

Cat:

SL14343R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep,Chimpanzee,)

Immunogen：

KLH conjugated synthetic peptide derived from human DLX3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

32kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]

Function:
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Subcellular Location:
Nucleus.

DISEASE:
Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO) [MIM:19064]. TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair.
Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4) [MIM:104510]; also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers.

Similarity:
Belongs to the distal-less homeobox family.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 1747 Human

Entrez Gene: 13393 Mouse

Entrez Gene: 287638 Rat

Omim: 600525 Human

SwissProt: O60479 Human

SwissProt: Q64205 Mouse

Unigene: 134194 Human

Unigene: 5194 Mouse

Unigene: 10960 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall