Rabbit Anti-DUB3/FITC Conjugated antibody

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Cytokine inducible Deubiquitinating Enzyme; Deubiquitinating enzyme 17-like protein 2; Deubiquitinating enzyme 3; Deubiquitinating protein 3; DUB-3; DUB3 protein; U17L2_HUMAN; Ubiquitin carboxyl-terminal hydrolase 17-like protein 2; Ubiquitin thio

Cat:

SL1488R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human DUB3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

60kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]

Function:
Deubiquitinating enzyme that specifically removes conjugated ubiquitin from CDC25A, thereby playing a key role in cell cycle regulation. Deubiquitination of CDC25A prevents its degradation by the proteasome during the G1/S and G2/M phases of the cell cycle and is required for cell-cycle progression. Has transforming capabilities on cell lines. May also function in cell apoptosis.

Subcellular Location:
Nucleus.

Tissue Specificity:
Broadly expressed.

Similarity:
Belongs to the peptidase C19 family. USP17 subfamily.

Database links:

Entrez Gene: 377630 Human

Omim: 610186 Human

SwissProt: Q6R6M4 Human

Unigene: 531448 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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