Rabbit Anti-DUS1L/FITC Conjugated antibody

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1110032N12Rik; dihydrouridine synthase 1 like (S. cerevisiae); DUS1; DUS1L; DUS1L_HUMAN; PP3111; PP3111 protein; RP23-99M13.5; tRNA-dihydrouridine synthase 1-like.

Cat:

SL14446R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human DUS1L

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

53kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
DUS1L is a 473 amino acid protein belonging to the DUS family and DUS1 subfamily that catalyzes the synthesis of dihydrouridine, a modified base located in the D-loop of many tRNAs. DUS1L binds FAD as a cofactor and is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

Similarity:
Belongs to the dus family. Dus1 subfamily.

Database links:

Entrez Gene: 64118 Human

Entrez Gene: 68730 Mouse

Entrez Gene: 246185 Rat

SwissProt: Q6P1R4 Human

SwissProt: Q8C2P3 Mouse

SwissProt: Q8K582 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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