background:
SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008]
Function:
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Subcellular Location:
Cytoplasm. Endosome membrane. Nucleus. Late endosome membrane. Recruited to the endosome membrane to participate in vesicle formation.
Similarity:
Belongs to the SNF8 family.
Database links:
Entrez Gene: 11267 Human
Entrez Gene: 27681 Mouse
Entrez Gene: 287645 Rat
Entrez Gene: 492771 Zebrafish
Omim: 610904 Human
SwissProt: Q8IXY3 Human
SwissProt: Q96H20 Human
SwissProt: Q9CZ28 Mouse
SwissProt: Q5RK19 Rat
SwissProt: Q5U3V9 Zebrafish
Unigene: 127249 Human
Unigene: 372235 Mouse
Unigene: 162167 Rat
Unigene: 117433 Zebrafish
Unigene: 84729 Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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