background:
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]
Edc3, enhancer of mRNA-decapping protein 3, is a 508 amino acid protein that maps to human gene EDC3. Edc3 is a member of the EDC3 family and contains one YjeF N-terminal domain. Edc3 is localized to the cytoplasm and is found primarily in the processing bodies (PBs) of the cell. Evidence indicates Edc3 also interacts with TTP (zinc finger protein 36), a candidate gene for obesity-related metabolic complications.
Function:
Binds single-stranded RNA. In the process of mRNA degradation, may play a role in mRNA decapping. May play a role in spermiogenesis and oogenesis.
Subcellular Location:
Cytoplasm; P-body. Processing bodies.
Tissue Specificity:
Expressed in theca and granulosa cells in ovary, and in spermatids of the meiotic division part II and apical membrane of Sertoli cells in testis (at protein level). Also expressed in brain and mammary gland.
Similarity:
Belongs to the EDC3 family.
Contains 1 DFDF domain.
Contains 1 YjeF N-terminal domain.
Database links:
Entrez Gene: 80153 Human
Entrez Gene: 453743 Chimpanzee
Entrez Gene: 101128321 Gorilla
Entrez Gene: 353190 Mouse
Entrez Gene: 100171859 Orangutan
Omim: 609842 Human
SwissProt: Q96F86 Human
SwissProt: Q8K2D3 Mouse
SwissProt: Q5RDU9 Orangutan
Unigene: 682454 Human
Unigene: 96852 Human
Unigene: 268104 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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