Rabbit Anti-EFHD2/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-EFHD2/FITC Conjugated antibody

EF hand domain containing protein 2; EF hand domain family, member D2; EF-hand domain-containing protein D2; EFHD 2; EFHD2; EFHD2_HUMAN; RP3-467K16.3; Swiprosin 1; Swiprosin-1; SWS1.

Cat:

SL14520R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human EFHD2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

27kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
EFHD2 is a 48 amino acid protein that regulates spontaneous apoptosis through the regulation of Bcl-xS abundance. Localized to membrane raft, Swiprosin-1 is expressed in lymphocytes and contains two EF-hand domains. The gene encoding Swiprosin-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Function:
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis (By similarity). Plays a role as negative regulator of the canonical NF-kappa-B-activating branch (By similarity). Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.

Subcellular Location:
Membrane raft. In immature B-cell line WEHI231.

Tissue Specificity:
Found in lymphocytes; preferentially expressed in CD8+ cells.

Similarity:
Contains 2 EF-hand domains.

Database links:

Entrez Gene: 7936 Human

Entrez Gene: 27984 Mouse

Entrez Gene: 298609 Rat

SwissProt: Q96C19 Human

SwissProt: Q9D8Y0 Mouse

SwissProt: Q4FZY0 Rat

Unigene: 465374 Human

Unigene: 395598 Mouse

Unigene: 92713 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall