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Rabbit Anti-ENTPD7/FITC Conjugated antibody
background:
LALP1 is a 604 amino acid multi-pass membrane protein that belongs to the GDA1/CD39 NTPase family. Preferentially hydrolyzing nucleoside 5’-triphosphates, LALP1 and has an order of activity with respect to possible substrates, which is UTP > GTP > CTP. The gene that encodes LALP1 consists of approximately 51,740 bases and maps to human chromosome 10q24.2. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of total DNA in cells and encodes nearly 1,200 genes. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Function:
The ENTPD7 belongs to the GDA1/CD39 NTPase family and the gene resides on chromosome 10q23-q24 and contains 12 exons and 11 introns covering a genomic region of approximately 46 kilobase pairs. The subcellular localization and enzymatic activity of ENTPD7 indicated that ENTPD7 is indeed an endo-apyrase with substrate preference for nucleoside triphosphates UTP, GTP, and CTP.
Subcellular Location:
Cytoplasmic intracellular multi-pass membrane protein. Localizes to vesicular compartments.
Similarity:
Belongs to the GDA1/CD39 NTPase family.
Database links:
Entrez Gene: 57089 Human
Entrez Gene: 93685 Mouse
Entrez Gene: 309390 Rat
SwissProt: Q9NQZ7 Human
SwissProt: Q3TCT4 Mouse
Unigene: 716513 Human
Unigene: 296789 Mouse
Unigene: 169265 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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